Ultrastructural Comparison of Two Human Malignant Melanoma
نویسندگان
چکیده
melanosomes; only the amount of melanosomes produced varied in the different strains. The strains in line MeGo varied widely in the appearance of their premelanosomes. The helical arrangement of the matrix filaments was missing, and cross-striated melanosomes were not seen. Morphologically, premelanosomes tend to resemble lysosomes in varying degrees in the different strains. Because all strains of both Unes are dihydroxyphenylalanine positive and show acid phosphatase activity in melanosomes, two possible explanations are considered: (a) hydrolytic enzymes function in the melanosome to terminate melanogenesis; or (¿>) the enzymes indicate hydrolysis of melanosomes as they accumulate in the melanoma cells.
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